Preheat the air fryer to 400 degrees F (200 degrees C).
Rinse and pat the catfish dry with a paper towel before coating.
Add the seasoned breading to a shallow bowl and dip each piece of fish until fully coated.
Lay out the nuggets on a baking sheet and spray with non-stick cooking spray.
Place the nuggets in an even layer in the air fryer basket, sprayed side down.
Cook for 8 minutes.
Flip the nuggets over and cook for an additional 4 minutes.
Take a Bibb lettuce leaf and place a piece of fried catfish in the center.
Add toppings: diced tomatoes, sliced red onion, cilantro, sliced avocado, and a dollop of tartar sauce.
Serve the Fried Catfish Lettuce Wraps immediately while the catfish is still crispy.
Garnish with lime and enjoy!